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In the case of 2-butoxyethanol,several PBPK models had been developed that could beused to determine the cross-species adjustment for TK.

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Breast cancer cells that have an over expression of the HER-2(human epidermal growth factor receptor-2) gene begin to express the high levels of IL-6.Secretion of IL-6 by these tumor cells is associated with the activation of STAT-3 in what iscalled an ?autocrine? loop where there is the perpetual release and use (IL-6R engagement) ofthe same IL-6 secreted by the tumor cell (Hartman 2011).

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Issues regarding selection of the appropriatespecies for extrapolation are discussed in Section 23.2. Scull comments that the work of social scientists on the disabling and custodialfunction of the asylum was not accompanied by evidence of greater public tolerance towards emo-tional deviance.
Bronies: Mythical Creature or Misinformed Man?

Bronies: Mythical Creature or Misinformed Man?

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