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Breast cancer cells that have an over expression of the HER-2(human epidermal growth factor receptor-2) gene begin to express the high levels of IL-6.Secretion of IL-6 by these tumor cells is associated with the activation of STAT-3 in what iscalled an ?autocrine? loop where there is the perpetual release and use (IL-6R engagement) ofthe same IL-6 secreted by the tumor cell (Hartman 2011).
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