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The N-terminus is divided in three subdomains: the transactivation domains 1 and 2(TAD1 and TAD2) and the proline-rich domain (PRD); the central domain is the DNA-bindingdomain (DBD); and, the C-terminus is formed by the nuclear localization sequence (NLS), theoligomerization domain (OD) and the regulatory domain (RD) [ 60 ]
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Most common locations are the sigmoid colonand rectum (Markowitz and Winawer 1997).
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